Lam, Aoife Ward, Omer Gilan, Yih-Chih Chan, Antje Hienzsch, Anna Rutkowska, Thilo Werner, Anne J. Tyler, Johanna Vappiani, Tatiana Cañeque, Enid Y. Nature Comm. 9, (2018).Ĭlick chemistry enables preclinical evaluation of targeted epigenetic therapies.

Karp, James Atkinson, Andrea Kirton, Matt Jacobsen, Dean Clift, Sanger Mouse Genetics Project, Raphaël Rodriguez, David J. Barros, Casey Collins, Monica Abrudan, Mukerrem Demir, Nicola Geisler, Christopher J. Targeting NAT10 enhances healthspan and lifespan in a mouse model of human accelerated aging syndrome. Visualizing biologically active small molecules in cells using click chemistry. Tatiana Cañeque, Sebastian Müller, Raphaël Rodriguez*. Rossignol, Sebastian Müller, Tatiana Cañeque,Raphaël Rodriguez and Fatima Mechta-Grigoriou. PML-dependent metabolic heterogeneity enhances chemosensitivity in human ovarian cancers. Salinomycin Derivatives Kill Breast Cancer Stem Cells via Lysosomal Iron Targeting. Nature Chem., 2020, 12, 929–938.ĭMT1 Inhibitors Kill Cancer Stem Cells by Blocking Lysosomal Iron Translocation. Metallomics 2021ĬD44 regulates epigenetic plasticity by mediating iron endocytosis. The group seeks to employ universal principles of physical chemistry and knowledge of biology to impact human medicine.Ĭhemistry and Biology of Ferritin.M. The lab is currently focused on developing methods for personalised cancer treatments and elucidating roles of iron in the maintenance of mesenchymal cancer cells. During the course of our studies, these unbiased methods have led to the identification of novel therapeutic targets such as the lysine acetyl transferase NAT10 as a master regulator of ageing, iron homeostasis has a druggable network in mesenchymal cancer cells and new anti-cancer strategies that consist of altering the chromatin landscape to control genome targeting with cisplatin drugs.

These includes cutting-edge small molecule imaging in cells by means of click chemistry, next generation sequencing and quantitative proteomics. We custom design new probes and protocols to delineate mechanisms of action of small molecules. We study cell biology at the molecular level using an integrated approach combining synthetic organic chemistry and molecular biology techniques. Our laboratory has adopted ‘the small molecule approach’ to biology. It is my opinion that life has evolved mechanisms to circumvent undesired chemistry’’ -Raphaël Rodriguez-Ĭongratulations to Raphaël for the Tetrahedron Young Investigator Award for Bioorganic and Medicinal Chemistry 2019.Ģ019 Grand Prix de l’Institut de France ‘Charles Defforey’ While biology is prone to evolution, universal principles of physical chemistry are not (at least not on the same time scale). “Nature is dominated by chemically favoured processes. Raphaël Rodriguez Group Leader, DR2 CNRS *protected email*

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